Biochemistry — ATP Depletion

⚡ Low Energy State

When ATP runs out, cells start dying in tissue-specific ways. Each deep dive below covers how a different organ system handles energy failure — what breaks first, what's reversible, and the high-yield board distinctions.

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Core Concepts
The universal ATP depletion cascade. Na/K pump failure, calcium influx, mitochondrial damage. Reversible vs irreversible injury markers.
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Breast & Marrow
Fat necrosis in breast tissue, marrow infarction in sickle cell. How high metabolic demand meets poor collateral circulation.
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Repro, Endo & Marrow
Ovarian torsion, adrenal crisis, bone marrow aplasia. Hormone-dependent tissues and the consequences of ischemia.
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Respiratory & Renal
ATN vs cortical necrosis, pulmonary infarction. Why kidneys get ATN first and lungs resist infarction (dual blood supply).
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Uterus & Vessels
Uterine fibroid degeneration, vascular smooth muscle response to hypoxia. Endometrial shedding as physiologic ischemia.
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Vascular & Uterus
Atherosclerotic plaque instability, aortic aneurysm, placental insufficiency. Large vessel ischemia and downstream tissue death.
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Vessels & Uterus
Microvascular disease, DIC, pre-eclampsia. Small vessel ischemia patterns and coagulation cascade in energy-depleted states.